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V79 | ||||
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| Product Name | V79 | |||
| Price | Get Quote | |||
| Product Code | V-79; V 79; Strain V; V79-1 | |||
| Cat.No | ABC-TC1270 | Species | Cricetulus Griseus | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description |
Why choose V79 from AcceGen? V79 cells from AcceGen offer exceptional quality and viability. They are cultivated under optimal conditions, cryopreserved by skilled operators, and undergo rigorous quality control. These cells are sterile, mycoplasma-negative, and undergo daily monitoring to ensure the absence of bacteria and fungi, guaranteeing their reliability for research purposes. | |||
| Source Organ | Lung | |||
| Recommended Medium And Supplement | DMEM + 10% FBS | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY V79 cells hold significant prominence in DNA repair and damage research, primarily due to their distinct attributes, including a truncated G1 phase, karyotype stability, and the absence of endogenous cytochrome P450 expression. These cells find utility in gene toxicity assays and facilitating the expression of exogenous P450 enzymes from diverse species. Furthermore, their suitability for the establishment of stable mutant cell lines proves invaluable in investigating DNA repair enzymes. Notwithstanding certain concerns, V79 cells have played a pivotal role in the study of DNA damage and repair mechanisms induced by various agents, such as x-rays, UV radiation, and oxidizing agents. | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Fibroblast | |||
| Growth Mode | Adherent | |||
| Product Type | Cricetulus Griseus Lung Cell Lines | |||
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The V79 cell line, derived from the spontaneous transformation of lung cells isolated from a male Chinese hamster, exhibits several noteworthy characteristics. Notably, these cells display an abbreviated or entirely absent G1 phase, and they lack endogenous cytochrome P450 expression. The V79 cell line features a relatively prolonged doubling time, estimated at around 18-20 hours. A distinctive feature of V79 cells is their incapability to express the normal p53 protein and their failure to induce the mdm2 gene product in response to DNA damage. For subculturing, it is advisable to employ a 1:5 to 1:10 split ratio every 2-3 days, with cell detachment achievable through pipetting with PBS or mild treatment using trypsin/EDTA.
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