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Transfected Stable Cell Lines

TRAF2 Knockout Cell Lysate

  • BSL
  • 114
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation […]
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The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]

Species

Human

Cat.No

ABC-KC2165

Product Category Transfected Stable Cell Lines
Size/Quantity

100ug

Shipping Info

Ice Pack

Growth Conditions

37 ℃, 5% CO2

Storage

Store TRAF2 KO Cell Lysate At -20℃. Please Avoid Repeated Freeze-Thaw Cycles.

Product Type

CRISPR Knockout Cell Lysate

Host Cell

HEK293T

Citation

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Application

  • For research use only

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