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THP-1 is a monocyte cell line derived from the peripheral blood of an acute monocytic leukemia patient. These cells possess Fc and C3b receptors but lack surface or cytoplasmic immunoglobulins. Notably, the HLA haplotypes of THP-1 are HLA-A2, -A9, -B5, -DRW1, and -DRW2. The monocytic nature of THP-1 cells is evident through various characteristics, including the presence of α-naphthyl butyrate esterase activities that are susceptible to NaF inhibition, lysozyme production, phagocytosis capability for latex particles and sensitized sheep erythrocytes, and the ability to restore T-lymphocyte response to Con A.
Why choose THP-1 from AcceGen?
THP-1 cells boast high viability and quality, maintained under sterile, mycoplasma-free conditions with optimal incubation. They are cryopreserved by professional operators and undergo rigorous quality control, ensuring their reliability and suitability for various research applications.
| Product Code | THP1; THP 1; THPI |
| Species | Human |
| Cat.No | ABC-TC1234 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Monocyte |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Blood |
| Disease | Acute Myeloid Leukemia |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
THP-1 cells find diverse applications due to their unique characteristics. They serve as an ideal transfection host, facilitating genetic studies and manipulation. Additionally, these cells offer valuable insights into monocyte biology and immune responses, acting as a multifaceted model for studying monocyte-macrophage differentiation. Moreover, THP-1 cells prove invaluable in investigating the immune-modulating effects of compounds under both activated and resting conditions, making them essential in drug development and immunological research.
