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Tumor Cell Lines

THLE-2

  • BSL

    2

  • 129
THLE-2 cell line was derived from primary normal liver cells by infection with SV40 large T antigen. These immortalized human liver cells constitute an in vitro model for pharmacotoxicological studies and for the investigation of etiology and pathogenesis of human hepatocellular carcinoma.
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THLE-2 cells are immortalized human adult liver epithelial cells modified with recombinant simian virus 40 large T antigen virus. These cells have undergone more than 100 population doublings and exhibit a near-diploid karyotype. They have been found to be non-tumorigenic when injected into athymic nude mice. Notably, THLE-2 cells do not express alpha-fetoprotein.

In the early passage, THLE-2 expresses cytokeratin 18 and albumin. However, higher-passage cells in logarithmic-phase growth also express cytokeratin 19. THLE-2 cells possibly possess functional cytochrome P450 pathways, as they are able to metabolize benzo[a]pyrene, N-nitrosodimethylamine, and aflatoxin B1 into their ultimate carcinogenic metabolites that adduct DNA. These cells retain various enzymes involved in the metabolism of chemical carcinogens, including epoxide hydrolase, NADPH cytochrome P450 reductase, superoxide dismutase, catalase, glutathione S-transferases, and glutathione peroxidase.

 

Why choose THLE-2 from AcceGen?

THLE-2 cells possess several notable features. They are sterile and rigorously tested to ensure they are negative for bacteria, fungi, and mycoplasma contamination, ensuring the purity of the cell line. These cells exhibit high viability, enabling robust experimental results. They are also subjected to professional cryopreservation methods, allowing for long-term storage and convenient access. Furthermore, THLE-2 cells undergo rigorous quality control measures, guaranteeing their reliability and consistency for various research applications.

Product Code

THLE2; Transformed Human Liver Epithelial-2

Species

Human

Cat.No

ABC-TC1337

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Biosafety Level

2

Storage

Liquid Nitrogen

Product Type

Human Liver Cell Lines

Citation

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Application

  • FOR RESEARCH USE ONLY

  • THLE-2 cells serve as valuable models for studying xenobiotic metabolism and toxicity. They are widely utilized to elucidate insulin-dependent signaling pathways and the regulation of hepatic metabolism. These cells are also employed as an in vitro model for pharmacotoxicological studies, allowing researchers to assess the potential adverse effects of drugs and other substances on liver function. Additionally, THLE-2 cells are valuable tools for investigating the etiology and pathogenesis of human hepatocellular carcinoma, offering insights into the development and progression of this type of liver cancer.

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High Viability
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Tags

  • Human (1729)
  • Liver (143)
  • Normal (1578)
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