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T-47D is a human epithelial cell line originally isolated from a pleural effusion obtained from a 54-year-old female patient diagnosed with infiltrating ductal carcinoma of the breast. This differentiated epithelial sub-strain exhibits distinctive characteristics,
including the presence of cytoplasmic junctions and the expression of receptors for 17-beta-estradiol, along with other steroids and calcitonin. Notably, T-47D cells have the unique ability to form colonies in soft agar, which is instrumental in various research applications. Additionally, these cells are known for their high expression of the Wnt-7b oncogene and their positive status for estrogen and progesterone receptors, while displaying comparatively lower levels of androgen and glucocorticoid receptor expression.
Why choose T-47D from AcceGen?
The T-47D cell line provided by AcceGen stands out for its robust viability and superior quality. Maintained under stringent sterile conditions, it undergoes rigorous screening to guarantee its purity by ensuring it is free from contaminants like bacteria, yeast, mycoplasma, and human pathogens, including HIV-1, HBC, and HCV. Additionally, the cell line’s identity is confirmed through STR analysis, reinforcing its authenticity and making it a highly dependable choice for research and experimental work.
| Product Code | T-47-D; T47-D; T47D:A; T47D |
| Species | Human |
| Cat.No | ABC-TC1217 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Breast Ductal Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Breast Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The T-47D cell line plays a pivotal role in advancing breast cancer and hormone receptor-related research. These cells have been instrumental in investigating the impact of progesterone on breast cancer and deciphering the transcriptional regulation induced by various therapeutic agents. Furthermore, T-47D cells can be utilized to establish xenograft models in immunodeficient mice, enabling researchers to conduct drug testing while assessing receptor status and monitoring angiogenesis changes, thus offering crucial insights into cancer treatment strategies.
