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| Product Code | SKN3 |
| Species | Human |
| Cat.No | ABC-TC1043 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Oral Cancer Cell Lines |
The SKN-3 cell line is a human oral squamous cell carcinoma (OSCC) cell line derived from xenotransplantation in mice. It exhibits patchy methylation of CpG sites and carries a mutant nuclear receptor binding SET domain protein 1 (NSD1). 
SKN-3 lacks the imprint gene, paternally expressed gene 1/mesoderm-specific transcript (PEG1/MEST). It also shows high expression of p21 activated kinase 4 (PAK4), a gene with a proliferation-boosting effect in oral squamous cell carcinoma. Targeting PAK4 using miR1405P leads to a significant reduction in tumor growth (both weight and volume). The cell line is passaged using 0.25% trypsin and 0.02% EDTA and has a doubling time of approximately 36-40 hours.
Why choose SKN-3 from AcceGen?
The SKN-3 cell line exhibits high quality and viability, cultivated under optimal conditions with rigorous quality control. It is maintained in a sterile environment, ensuring it is free from human pathogens, fungi, bacteria, and mycoplasma. Additionally, advanced cryopreservation techniques are employed to preserve the cell line effectively.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Peng, M., & Pang, C. (2019). MicroRNA‐140‐5p inhibits the tumorigenesis of oral squamous cell carcinoma by targeting p21‐activated kinase 4. Cell Biology International, 44(1), 145-154. https://doi.org/10.1002/cbin.11213
FOR RESEARCH USE ONLY
The SKN-3 cell line serves as a valuable tool in various applications related to oral squamous cell carcinoma (OSCC). It is utilized to study the development and progression of OSCC, providing insights into the tumorigenic mechanisms underlying head and neck cancers. Additionally, researchers use SKN-3 cells to investigate genetic and epigenetic mechanisms that may play pivotal roles in oral tumorigenesis. Moreover, the cell line helps examine the functions of key factors in signaling pathways that promote cancers, making it a promising target for potential therapies against multiple cancer types.
