SK-N-SH
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The SK-N-SH cell line, established in 1970 from metastatic cells found in the bone marrow aspirate of a four-year-old female, is a well-known human neuroblastoma cell line extensively utilized in biomedical research. These cells exhibit neuronal characteristics and are commonly employed in studies related to neurobiology, neurodevelopment, and neurotoxicity. SK-N-SH cells have played a crucial role in elucidating molecular mechanisms underlying various neurological diseases and disorders, including Alzheimer’s disease, Parkinson’s disease, and neurodevelopmental disorders. Renowned for their capacity to differentiate into mature neuronal-like cells, they serve as a valuable tool in drug discovery and screening assays aimed at identifying potential treatments for neurological conditions. Additionally, SK-N-SH cells have been pivotal in investigations exploring neuronal differentiation pathways, synaptic transmission, and neuroprotective strategies.
The SK-N-SH cell line is hyperdiploid human female (XX), with a modal chromosome number of 47. Normal chromosomes N9 and N22 are single, while chromosome N7 is trisomic. Structural alterations have formed two marker chromosomes, 9q+ and 22q+, with extra bands present on one copy of chromosome N7, resulting in the formation of a marker chromosome as described by R.C. Seeger. These cells may have been translocated in part(s) to the q arms of chromosomes N9 and N22.
Why choose SK-N-SH from AcceGen?
Elevate your neuroscience research with AcceGen’s SK-N-SH, a cutting-edge human neuroblastoma cell line meticulously cultivated to meet the highest standards of quality and reliability.
Key Features:
Comprehensive Quality Control
Our commitment to excellence is reflected in our comprehensive quality control tests:
Sterility: Negative for contamination, including bacterial, fungal, and mycoplasma (PCR), and free from human pathogens.
Viability: Post-thaw viability exceeds 95%, providing robust and reliable cells for your experiments.
Identity Verification with STR Analysis
Upholding the highest standards of authenticity, we perform Short Tandem Repeat (STR) analysis using 16 probes, including 15 STR loci and Amelogenin. This ensures the unequivocal identity of our SK-N-SH cells.
Optimal Growth Characteristics
Experience optimal growth with SK-N-SH cells, characterized by meticulous assessments of morphology and immunocytochemistry of multiple undifferentiation markers.
| Product Code | SK N SH; SKN-SH; SK-NSH; SKNSH; NSH |
| Species | Human |
| Cat.No | ABC-TC1049 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Bone Marrow |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Nerve Tumors Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
SK-N-SH is a human neuroblastoma cell line that is widely used in scientific research, particularly in the field of neuroscience. Here are some key applications of SK-N-SH cells in science research:
Neurobiological Studies
SK-N-SH cells serve as a valuable model for studying neurobiological processes, including neuronal development, differentiation, and function. Researchers use these cells to investigate the molecular and cellular mechanisms underlying neural processes.
Neurotoxicity Testing
SK-N-SH cells are employed in neurotoxicity studies to assess the impact of various substances, such as drugs or environmental agents, on neuronal viability and function. This is crucial for evaluating potential neurotoxic effects and understanding mechanisms of neuroprotection.
Neurodegenerative Disease Research
Researchers studying neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, use SK-N-SH cells to model disease processes. These cells help investigate the underlying causes of neurodegeneration and test potential therapeutic interventions.
Drug Discovery and Development
SK-N-SH cells are utilized in drug screening assays to assess the effects of compounds on neuronal cells. This is valuable in the early stages of drug discovery for identifying potential candidates for the treatment of neurological disorders.
Cell Signaling and Gene Expression Studies
SK-N-SH cells are employed to investigate cell signaling pathways and gene expression patterns associated with neuronal differentiation and function. Understanding these mechanisms can provide insights into normal neuronal processes and abnormalities in disease states.
Neuronal Differentiation Studies
SK-N-SH cells can be induced to differentiate into more mature neuronal phenotypes. This property makes them useful for studying the process of neuronal differentiation and for generating differentiated cell models for specific research purposes.
