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| Product Code | RPMI-2650 |
| Species | Human |
| Cat.No | ABC-TC0984 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Nose |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Other Cell Lines |
Derived from the nasal septum of a 52-year-old male patient afflicted with squamous cell carcinoma, RPMI 2650 is an epithelial cell line characterized by its distinctive morphological features. Immunoperoxidase staining confirms their positive keratin status. Mimicking the structure of nasal mucosa, these cells assemble into a polarized epithelium and showcase the presence of occludin, claudin-1, and E-cadherin, reminiscent of their natural counterparts. Interestingly, cells cultivated at the air-liquid (A-L) interface exhibit enhanced layering, elevated transepithelial electrical resistance (TEER), and reduced dextran and jacalin permeability compared to those at the L-L interface, which present a more differentiated appearance. Remarkably, these cells are proficient in TGF-beta secretion and display heightened responsiveness to stimuli such as HDM allergens and TNF-alpha, prompting amplified TGF-beta gene expression and subsequent protein release.
Why choose RPMI 2650 from AcceGen?
RPMI 2650 cells are distinguished by their excellent viability and quality, thriving under optimal incubation conditions. These cells arrive in a sterile state, having undergone advanced cryopreservation techniques, and are subject to rigorous quality control, ensuring reliability and consistency for diverse research needs.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The RPMI 2650 cell line plays a pivotal role in advancing medical research by facilitating early assessments of innovative interventions aimed at addressing irregular reactions of upper airway structural cells. Serving as an in vitro model for nasal mucosa, this cell line proves invaluable for investigating drug permeability and screening potential nasal drug candidates. Moreover, its significance extends to studying the intricate regulation of TGF-beta biology, solidifying RPMI 2650 as a robust tool for enhancing our understanding of various therapeutic strategies.
