RD
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Rhabdomyosarcoma (RD) cells are large, multinucleated, spindle-shaped cells isolated from muscle tissue. RD was derived directly from biopsy specimens of a 7-year-old female with a pelvic RMS previously treated with cyclophosphamide and radiation and found to have refractory disease . It has an embryonal histology based on histologic appearance of the tumor biopsies and the cultured cells, and 51-hyperdiploid chromosomes. RD has been shown to have amplification of the MYC oncogene, Q61H mutation of NRAS, and homozygous mutation of TP53.In addition, another study has shown that this line is at least parental, if not identical, to TE-671.
Why choose RD from AcceGen?
AcceGen’s Rhabdomyosarcoma (RD) cells offer a reliable and scientifically validated cell line that empowers your research in oncology, cell biology, and beyond. Trust in the quality and precision of our RD cells to advance your biomedical studies with confidence. Explore new horizons in understanding Rhabdomyosarcoma and contribute to advancements in cancer research.
Key Features:
Meticulous Quality Control
Our commitment to excellence is reflected in rigorous quality control tests:
Sterility: Confirmed negative for bacterial, fungal, and Mycoplasma (PCR) contamination, ensuring a pristine culture environment.
Viability: Post-thaw viability exceeds 95%, providing robust and reliable cells for your experiments.
Identity Verification with STR Analysis
Upholding the highest standards of authenticity, we perform Short Tandem Repeat (STR) analysis using 16 probes, including 15 STR loci and Amelogenin. This ensures the unequivocal identity of our RD cells.
Optimal Growth Characteristics
Experience optimal growth with RD cells, characterized by meticulous assessments of morphology and immunocytochemistry of multiple undifferentiation markers.
| Product Code | R D; RD-2; RD 2; 130T; 130-T; 130 T; TE-32; TE 32; TE32; TE 32.T; Te 32.T |
| Species | Human |
| Cat.No | ABC-TC0954 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Muscle |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Myoma Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The RD cell line stands as a cornerstone in rhabdomyosarcoma (RMS) research, being extensively employed to investigate various aspects of tumor behavior and response to therapeutic agents. A pivotal study conducted by Houghton et al. delved into the impact of different chemotherapy agents on tumor size, revealing that RD cells exhibited notable growth inhibition in response to vincristine and cyclophosphamide, distinguishing their unique sensitivity among the agents tested. Additionally, RD served as a valuable model for assessing the effects of tolfenamic acid, showcasing reduced tumor size, diminished cell migration, and decreased expression of Sp specificity transcription factors post-treatment.
The RD cell line remains a fundamental tool in the realm of multistage carcinogenesis studies, providing a robust and enduring in vitro model for understanding the complexities of tumor development. Its longevity and widespread utilization underscore its significance in advancing biomedical knowledge and therapeutic insights in cancer research.
