Rat Liver Kupffer Cells, isolated from healthy rat liver, are crucial sentinel cells in the liver’s immune defense system. These specialized macrophages constitute 31% of the sinusoidal cells and are strategically distributed within liver lobules, with 43% in the periportal, 28% in the midzonal, and 29% in the central areas. Kupffer cells exhibit remarkable longevity and self-renewal capabilities under physiological conditions. They serve a pivotal role in safeguarding the liver by recognizing and responding to pathogens and metastatic cells, all while maintaining tolerance to harmless self and foreign antigens. Additionally, these cells are central players in liver-related pathologies, including fibrosis, inflammation, alcoholic liver disease, fatty liver disease, and liver transplantation, contributing significantly to liver health and disease management.
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