Rat cortical astrocytes, originating from the rat cerebral cortex, constitute the predominant cell type in the central nervous system, exerting diverse roles crucial for neural health. They offer mechanical support and essential nutrients to neurons while aiding in waste removal. These versatile cells also engage in signaling with endothelial cells, oversee neurogenesis, and modulate synaptic activity. Their pivotal functions become evident in situations like stroke, where any disruption in their regular activities can profoundly impact neuron survival. Furthermore, their expression of surface molecules and release of trophic factors play an integral role in promoting long-term recovery following brain injuries, facilitating processes such as neurite outgrowth, synaptic plasticity, and neuron regeneration.
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