Rat Aortic Endothelial Cells

Rat Aortic Endothelial Cells (RAEC), isolated from the rat aorta, are a pivotal component of the blood-tissue interface. They exhibit a dichotomous functionality, generating both antithrombotic factors such as tissue-type plasminogen activator (t-PA) and prothrombotic elements like plasminogen activator inhibitor-1 (PAI-1). Upon stimulation by tumor necrosis factor-alpha (TNFalpha), RAEC undergo alterations in growth characteristics and release cytokines, notably granulocyte-macrophage colony-stimulating factor (GM-CSF). Moreover, RAEC exhibit reduced permeability in response to Intermedin (IMD) due to the enhanced accumulation of VE-cadherin at their intercellular junctions. Consequently, these cells serve as an invaluable model for investigating vascular physiology and the intricate regulation of blood-tissue interactions.

Why choose Rat Aortic Endothelial Cells from AcceGen?

Rat Aortic Endothelial Cells from AcceGen are of exceptionally high quality, isolated from adult rat aorta and cryopreserved at the early passage, with each vial containing over 0.5×10⁶ cells. Each lot undergoes rigorous testing for proper morphology, population doublings, and is confirmed to be free from HIV, Hepatitis B, Hepatitis C, mycoplasma, bacteria, and fungi. These cells are capable of being cultured up to at least the 6^th passage, making them a reliable and durable resource for research applications.