PSN1
1
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The PSN-1 cell line is derived from a pancreatic adenocarcinoma patient. It was established through transplantation into nude mice, originating from the xenograft. Remarkably, PSN1 cells maintain the same elevated levels of both c-myc (50-fold) and activated c-Ki-ras (3-6 fold) with a specific mutation (GGT to CGT at codon 12) as found in the original tumor. Additionally, increased c-myc and c-Ki-ras transcripts are present. The cell line shows loss of one p53 allele and a mutation (AAG to CAG at codon 132) in the remaining allele. PSN1 is cultured continuously as a monolayer with an epithelial morphology.
Why choose PSN1 from AcceGen?
AcceGen offers the PSN1 cell line characterized by excellent viability and quality. Provided sterile and maintained by skilled professionals under optimal conditions, it undergoes rigorous quality control. The human origin is validated through species verification by isoenzyme testing, further confirmed by its Short Tandem Repeat (STR) profile for accurate identification.
| Product Code | PSN-1 |
| Species | Human |
| Cat.No | ABC-TC0915 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Disease | Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Pancreas Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The PSN-1 cell line finds valuable application in the exploration of pancreatic cancer and the development of potential therapeutic interventions, including strategies such as chemoradiation treatment. This cell line’s significance lies in its representation of a cancer cell with intricate genetic alterations involving oncogenes (c-Ki-ras and c-myc) and a tumor suppressor gene (p53). Notably, PSN1 has been utilized for in vitro investigations, such as the study of synthetic acetylhomoagmatine, as well as for assessing the cytotoxicity of irinotecan and topotecan. These applications highlight PSN-1’s crucial role in advancing our understanding of pancreatic cancer and aiding the design of targeted treatment approaches.
