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PFKFB4 Knockout Cell Lysate

  • BSL
  • 90
The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount […]
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Home | Transfected Stable Cell Lines | Knockout Cell Lysate | PFKFB4 Knockout Cell Lysate
Species

Human
Cat.No

ABC-KC1443
Product Category Transfected Stable Cell Lines
Size/Quantity

100ug
Shipping Info

Ice Pack
Growth Conditions

37 ℃, 5% CO2
Storage

Store PFKFB4 KO Cell Lysate At -20℃. Please Avoid Repeated Freeze-Thaw Cycles.
Product Type

CRISPR Knockout Cell Lysate
Host Cell

HeLa

Description

The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

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