1
Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.
| Product Code | PC3; PC.3 |
| Species | Human |
| Cat.No | ABC-TC0903 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Prostate |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Prostate Cancer Cell Lines |
PC-3 is a cell line derived from a bone metastasis of a grade IV prostatic adenocarcinoma in a 62-year-old White male, known for its high metastatic potential. Notably, PC-3 cells are androgen-independent, unresponsive to androgens, glucocorticoids, or fibroblast growth factors, and instead, they are influenced by epidermal growth factors. Unlike other prostate cancer cell models, they exhibit low testosterone-5-alpha reductase and acidic phosphatase activity and do not express prostate-specific antigen (PSA). PC-3 cells are characterized by their small-cell neoendocrine carcinoma phenotype and exhibit distinctive morphological and molecular features. In terms of size, PC-3 cells measure approximately 15.1 to 16.6 micrometers in diameter.
Why choose PC-3 from AcceGen?
PC-3 cells exhibit high viability and quality, ensuring robust experimental outcomes. They are maintained under sterile conditions, rigorously tested to be negative for bacteria, fungi, and mycoplasma contamination, and their identity is confirmed through STR analysis, emphasizing their reliability and adherence to stringent quality control standards.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Saranyutanon, S., Deshmukh, S.K., Dasgupta, S., Pai, S., Singh, S. and Singh, A.P., 2020. Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers, 12(9), p.2651.
FOR RESEARCH USE ONLY
The PC-3 cell line is a crucial asset in prostate cancer research, allowing scientists to delve into biochemical alterations and assess how advanced prostate cancer cells respond to various chemotherapeutic agents. Beyond this, PC-3 cells are commonly employed in studies focusing on viral infections 
within mammalian cells that display an immune response. Their versatility extends to serving as a suitable host for transfection experiments, making PC-3 cells a versatile tool for researchers across diverse fields. They are particularly valuable for investigating the intricacies of the tumor environment and evaluating the efficacy of therapeutic drugs.
