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| Product Code | ONS76 |
| Species | Human |
| Cat.No | ABC-TC0875 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Nerve Tumors Cell Lines |
ONS-76 is a human medulloblastoma cell line that originated from a primary culture of cerebellar tumor tissue obtained from a 2-year-old girl. Notably, ONS-76 cells exhibit characteristics of neuronal cells, as evidenced by the presence of neuron-specific enolase (NSE) and neurofilament protein (NFP) in their cytoplasm. Moreover, when treated with interferon-gamma (IFN-γ), ONS-76 cells express class I and II major histocompatibility complex (MHC), suggesting their ability to differentiate into both neural and glial cells.
ONS-76 is believed to possess neural stem cell-like properties and can remain undifferentiated or in an early differentiation state. These cells form distinct colonies with high plating efficiency. They carry wild-type p53. ONS-76 exhibits a high proliferation potential and demonstrates tumorigenicity in vivo. Additionally, it displays elevated gene expression of CDH5 (VE-cadherin) and a significant percentage of CD144/VE-cadherin positive cells.
Why choose ONS-76 from AcceGen?
ONS-76 from AcceGen is an excellent choice due to its high viability and plating efficiency, ensuring reliable experimental results. Additionally, the cells are provided in a sterile state and prepared under optimal and standardized conditions, guaranteeing their quality. AcceGen maintains rigorous quality control measures, further ensuring the reliability and consistency of ONS-76 for research purposes.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
ONS-76 has found various applications in research and scientific investigations. It serves as a valuable model for conducting in vitro chemosensitivity tests with different antitumor agents against tumor cell lines. Furthermore, ONS-76 is utilized to explore the radio-resistance of medulloblastoma, aiding in understanding the response of these tumor cells to radiation treatment. Additionally, ONS-76 is employed to investigate the role of class II major histocompatibility antigens in the immune response, particularly on human medulloblastoma cells with neuronal differentiation. Lastly, this cell line contributes to studying the mechanisms involved in the differentiation of immature bipotential cells into both neuronal and glial cells, shedding light on the intricate process of cell development and differentiation.
