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Tumor Cell Lines

OCI-AML2

  • BSL

    1

  • 576
Tissue: peripheral blood; Tumor: leukemia, acute myeloid. Retinoic acid receptor gene expression.
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Home | Tumor Cell Lines | Human Tumor Cell Lines | OCI-AML2
Product Code

OCI/AML-2; OCIAML-2; OCI-AML2; OCI/AML2; OCI AML2; OCIAML2; AML-2
Species

Human
Cat.No

ABC-TC480S
Product Category Tumor Cell Lines
Size/Quantity

1 vial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Acute Myeloid Leukemia
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Human Leukemia Cell Lines

Description

Brightfield micrograph of OCI-AML2, showing suspension growth, 10X magnification.
OCI-AML2 is a human acute myeloid leukemia (AML) cell line derived from the peripheral blood of a 65-year-old male diagnosed with FAB M4 subtype in 1986. These cells exhibit typical round to oval morphology and grow in suspension without adherence. OCI-AML2 expresses hepatocyte growth factor (HGF), resulting in autocrine activation of the MET receptor tyrosine kinase, which supports cell survival, proliferation, and disease progression. The cell line is tumorigenic and capable of metastasis, making it highly suitable for studying AML signaling pathways, drug sensitivity, and disease relapse. Cells are pathogen-free (mycoplasma, bacteria, yeast, fungi), non-viral (HPV, HIV-negative), and are cryopreserved for consistent experimental use. It is widely used in both academic and pharmaceutical leukemia research.

OCI-AML2

AcceGen product mpp-89 cell line

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Citation

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Application

  • OCI-AML2 cell line is broadly applied in leukemia research. It serves as a valuable tool for investigating AML cell biology and treatment response of acute myeloid leukemia (AML) cells. Researchers rely on OCI-AML2 to gain insights into the role of DNMT3A in leukemogenesis and to establish connections between drug response and DNMT3A mutational status across different AML genetic backgrounds. Furthermore, OCI-AML2 is employed in the designing targeted therapies against AML-driving receptors in AML by designing approaches that block compensatory ligand expression.

Frequently Asked Questions

  • What are OCI-AML2 cells?

    OCI-AML2 is a human acute myeloid leukemia (AML) cell line used in leukemia research.

  • What culture medium is recommended for OCI-AML2 cells?

    The recommended culture medium is alpha-MEM supplemented with 20% fetal bovine serum.

  • How often should the medium be changed for OCI-AML2 cells?

    The medium should be changed every 2-3 days to ensure optimal growth conditions.

  • What is the recommended seeding density for OCI-AML2 cells?

    Approximately 1×10^5 cells/mL.

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