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Human Liver Intrahepatic Biliary Epithelial Cells-Passage 1 | ||||
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| Product Name | Human Liver Intrahepatic Biliary Epithelial Cells-Passage 1 | |||
| Price | Get Quote | |||
| Cat.No | ABC-TC001G | Species | Human | |
| Cell Type | Epithelial | |||
| Growth Mode | Adherent | |||
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Intrahepatic biliary epithelial cells (IBEpiC) are epithelial cells that line the intrahepatic bile ducts, a network of small tubes that carry bile within the liver. Current understanding suggests that they are derived from hepatoblasts, which are also precursor cells to hepatocytes. The human intrahepatic biliary epithelium is formed by ducts of different sizes and cholangiocytes of different cell areas. IBEpiC have complex physiological and metabolic functions, participating in the liver metabolism, excretion and other physiological processes. They also play an active immunologic role in both innate and adaptive immune responses. Studies have shown that intrahepatic bile duct lesions, such as primary sclerosing cholangitis and cholangiocarcinoma, target intrahepatic bile duct epithelial cells, which in turn cause damage to the intrahepatic bile duct epithelium. Markers for IBEpiC include KRT7, KRT19, CK7, CK19, SOX9和SPP1.
Why choose Human Liver Intrahepatic Biliary Epithelial Cells-Passage 1 from AcceGen? Human IBEpiC from AcceGen are isolated from human liver tissue and have high viability. HIBEpiC are cryopreserved at passage one and delivered frozen. Each vial contains more than 5 × 105 cells in 1mL volume. Cells are negative for bacteria, yeast, fungi, and mycoplasma. | |||
| Disease | Normal | |||
| Source Organ | Whole Human Livers | |||
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. | |||
| Recommended Medium And Supplement | ABM-TM001G Normal Human Liver Intrahepatic Biliary Epithelial Cell Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY Human IBEpiC can be used as an in vitro model to study the pathogenesis of intrahepatic bile duct diseases, which is of great significance for improving diagnosis and treatment. Cholangiopathy is a chronic liver disease, including primary biliary cirrhosis, primary sclerosing cholangitis, polycystic liver disease, and cholangiocarcinoma. Due to the lack of effective medical treatment, it often progresses to end-stage liver disease with high morbidity and mortality. Therefore, the study of immune regulation in Human IBEpiC will help to develop new genetic or pharmacological strategies to treat cholangiopathy. The cells are not suitable for liver transplantation. | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Product Type | Intrahepatic Biliary Cells | |||
| Product Image |  | |||
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