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Transfected Stable Cell Lines

NFKB Reporter THP1 Cell Line

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The NF-KB/Rel signaling pathway includes NF-KB2 p52/p100, NF-KB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins act as dimeric transcription factors, controlling gene regulation in a wide range of biological processes, including innate and adaptive immunity, inflammation, stress response, B cell development, and lymphoid organ development. In the classical or non-classical pathways, NF-KB/Rel proteins are bound and inhibited by IKB proteins. Pro-inflammatory cytokines, LPS, growth factors, and antigen receptor activation stimulate the IKK complex (IKKβ, IKKα, and NEMO) to phosphorylate IKB proteins. Phosphorylation of IKB leads to its ubiquitination and proteasomal degradation, releasing the NF-KB/Rel complex. The active NF-KB/Rel complex is further activated by phosphorylation and translocated to the nucleus, inducing the expression of target genes.The NFKB Reporter THP1 Cell Line uses the THP-1 cell line as a tool cell, stably expressing the NFKB-Luc reporter gene through lentivirus infection, and can be used to detect NFKB signaling transduction. Upon activation by pro-inflammatory cytokines or lymphokine receptor agonists, endogenous NF-KB transcription factors bind to DNA response elements, inducing the transcription of luciferase reporter genes.

Species

Human

Cat.No

ABC-RC145F

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial

Cell Type

Monocyte

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Peripheral blood

Disease

Acute monocytic leukemia

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Reporter Stable Cell Lines

Host Cell

THP1

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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Application

  • For research use only

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