Nb2-11
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Nb2-11 is a clone of the Nb-2 rat lymphoma line which was derived from a transplant of a lymphoma that developed in the thymus/lymph node of a male noble (Nb) strain rat following prolonged oestrogen treatment. The cells are of the pre-T cell origin and their proliferation is dependent on mammalian lactogens, such as prolactin. Nb2-11 can also be mitogenically stimulated by IL-2. Injection of Nb2 cells into Nb rats gives rise to malignant tumours that are highly sensitive to treatment with vinca alkaloids. Karyotypic analysis has shown that the cell line has only five well developed chromosome abnormalities.
| Species | Rat |
| Cat.No | ABC-TC5569 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphoblast |
| Shipping Info | Dry ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Thymus |
| Storage | Liquid Nitrogen |
| Product Type | Rat Lymphoma Cell Lines |
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For research use only
Nb2-11 cells are lymphoblastoid cells which grow in suspension and clump to form clusters when they are close to full confluence.
The culture medium recommended for Nb2-11 cells is composed of Fischer’s medium supplemented with 0.075% Na Bicarbonate, 2mM Glutamine to support optimal cell growth and maintenance, add 0.05mM 2-Mercaptoethanol (2ME), 10% FBS and 10% HS. Nb2-11 cell culture does not have to use HEPEs.
It is recommended to seed at 4×1,000 and 12×1,000 cells/ml for culture periods of 96 and 72 hours respectively. Do not exceed 9×100,000 cells/ml. Check daily.
Nb2-11 is a clone of the Nb-2 rat lymphoma line, derived from a transplant of a lymphoma that developed in the thymus/lymph node of a male noble (Nb) strain rat following prolonged oestrogen treatment.
