Mouse_TLR3 Reporter 293 Cell Line

Toll-like receptors (TLRs) are a class of important protein molecules involved in the innate immune system, acting as a bridge between the innate and adaptive immune responses. TLR3, a pattern recognition receptor, is primarily expressed in the endoplasmic reticulum-lysosome compartments, detecting viral infections by binding to dsRNA. Apart from virus-induced dsRNA, endogenous dsRNA released during tissue damage can also activate TLR3. Synthetic dsRNA like Poly(I:C), Poly(A:U), and their derivatives can also activate TLR3. Upon activation, TLR3 translocates from the endoplasmic reticulum to the Golgi apparatus and lysosomes, interacts with the key protein MyD88 in the signaling pathways, and triggers downstream signals.The Mouse_TLR3 Reporter 293 Cell Line is a reporter gene cell line constructed based on the TLR3 signaling pathway. This cell line stably expresses the TLR3 gene and luciferase reporter gene, serving as a tool for evaluating the in vitro activation effects of dsRNA targeting TLR3.