Mouse Hepatocytes
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Mouse hepatocytes, isolated from the mouse liver using a meticulous process involving anesthesia, vena cava cannulation, calcium chelation, and collagenase perfusion, represent a crucial component of liver research. These hepatocytes exhibit a distinctive polar morphology, with varying cell surface proteins across different 3D surfaces. To replicate this polar arrangement in vitro, researchers often overlay the hepatocyte monolayer with substances like collagen or basement membrane extracts. This meticulous isolation and cultivation of mouse hepatocytes provide valuable tools for studying liver function, metabolism, and drug testing, contributing to our understanding of hepatic biology and its applications in biomedical research.
Why choose Mouse Hepatocytes from AcceGen?
Mouse Hepatocytes from AcceGen is preferred choice for research excellence. Our hepatocytes are freshly isolated upon demand, boasting exceptional viability and minimal batch-to-batch variation. We maintain stringent quality control, closely monitoring cell morphology, attachment efficiency, monolayer confluency, and long-term viability stability for cryopreserved hepatocytes, ensuring reliable and consistent results for your research needs.
| Species | Mouse |
| Cat.No | ABC-TC3928 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Hepatocyte |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Primary Cells |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Dong, J., Adami, E., Chothani, S.P., Viswanathan, S., Ng, B., Lim, W.W., Singh, B.K., Zhou, J., Ko, N.S., Shekeran, S.G. and Tan, J., 2020. Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis. bioRxiv.
Dong, J., Viswanathan, S., Adami, E., Singh, B.K., Chothani, S.P., Ng, B., Lim, W.W., Zhou, J., Tripathi, M., Ko, N.S. and Shekeran, S.G., 2021. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nature Communications, 12(1), pp.1-15.
Viswanathan, S., Ng, B., Widjaja, A.A., Pua, C.J., Tham, N., Tan, J., Cook, S.A. and Schafer, S., 2021. Critical Conditions for Studying Interleukin‐11 Signaling In Vitro and Avoiding Experimental Artefacts. Current protocols, 1(9), p.e251.
FOR RESEARCH USE ONLY
Mouse hepatocytes play a pivotal role in several biomedical applications, primarily serving as a cost-effective alternative for studying liver-specific functions. Their utility extends to preclinical drug development and safety testing, offering insights into drug-induced liver toxicity. As primary hepatocytes, they provide an ex vivo model for understanding liver physiology, filling a crucial gap due to the limited availability and high cost of primary human hepatocytes. This versatile tool facilitates valuable research across various disciplines, making it indispensable for advancing our knowledge of liver biology and enhancing drug safety assessments.
