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Mouse Hepatic Stellate Cells | ||||
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| Product Name | Mouse Hepatic Stellate Cells | |||
| Price | Get Quote | |||
| Product Code | MHSteC | |||
| Cat.No | ABC-TC3927 | Species | Mouse | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Mouse Hepatic Stellate Cells (MHSC) are liver-specific mesenchymal cells derived from mouse liver, constituting 5-8% of total liver cells. Integral to liver homeostasis, maintenance, and regeneration, they excel at retinol metabolism. While quiescent in health, they harbor ample vitamin A lipid droplets, a major systemic reserve. However, in response to liver injury, MHSCs transition into an activated state marked by proliferation,
Why choose Mouse Hepatic Stellate Cells from AcceGen? Mouse Hepatic Stellate Cells from AcceGen are cryopreserved at passage one, ensuring cell viability upon delivery. They have been rigorously characterized through immunofluorescence targeting desmin and/or α-actin, ensuring their authenticity. Importantly, they have been screened and found negative for mycoplasma, bacteria, yeast, and fungi, ensuring their purity. AcceGen provides the assurance of successful culture continuation under the recommended conditions, making them a dependable choice for your research endeavors. | |||
| Disease | Normal | |||
| Source Organ | Liver | |||
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. | |||
| Recommended Medium And Supplement | ABM-TM3927 Mouse Hepatic Stellate Cells Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY Mouse Hepatic Stellate Cells offer a robust model system for delving into various facets of liver metabolism and pathophysiology. Their application spans diverse cell-based assays, including toxicity assessment, drug screening, and metabolic studies. They emerge as a crucial resource in the study of liver fibrosis, offering insights that could drive innovative therapeutic strategies for hepatic fibrosis treatment, ultimately aiming to enhance patient outcomes and mitigate the impact of chronic liver injury. | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Stellate Cell | |||
| Growth Mode | Adherent | |||
| Product Type | Mouse Primary Cells | |||
| Product Image |  | |||
contractility, and chemotaxis. This activation contributes to liver fibrosis, underpinning ailments like hepatitis B and C, fatty liver disease, and diabetes. Consequently, understanding MHSCs holds pivotal insights into treating chronic liver diseases and their associated complications, including cirrhosis.Frequently Asked Questions
What role do Mouse Hepatic Stellate Cells play in liver disease progression?
These cells become activated during liver injury, contributing to fibrosis and scar tissue formation.
Can Mouse Hepatic Stellate Cells revert to a quiescent state after activation?
In some cases, with appropriate signals, they can return to a less active, quiescent state, though this is limited.
How do Mouse Hepatic Stellate Cells interact with other liver cell types?
They interact closely with hepatocytes and immune cells, influencing inflammation and tissue remodeling.
What signaling pathways are crucial for the activation of Mouse Hepatic Stellate Cells?
Key pathways include TGF-β, PDGF, and Hedgehog signaling, which drive the activation and proliferation of these cells.
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