Mouse Hippocampal Astrocytes

Description

Mouse hippocampal astrocytes are thought to form a highly coupled network. They contribute to neural functioning in the hippocampus, which is crucial for spatial memory formation. Disrupting this astrocyte network alters neuronal excitability and synaptic transmission in the hippocampus. In mouse models, inhibiting vesicle release from hippocampal astrocytes impairs recognition memory, while chemogenetic activation enhances contextual fear memory. These findings highlight the significant role of hippocampal astrocytes in hippocampus-dependent brain functions and behaviors. Their close interaction with neurons facilitates information processing and influences memory formation in the hippocampus.

Why choose Mouse Hippocampal Astrocytes from AcceGen?

Choosing Mouse Hippocampal Astrocytes from AcceGen offers several advantages. AcceGen provides high-quality astrocytes isolated from the hippocampus of neonate day two mice and cryopreserved at an early stage (P1) with a substantial cell count of >0.5 million cells per vial. These astrocytes express GFAP, a marker for astrocytic identification, and are free from various contaminants such as HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. Moreover, AcceGen’s astrocytes have the potential to be expanded for five population doublings using AcceGen’s recommended culture conditions. This ensures a reliable and abundant supply of mouse hippocampal astrocytes for research purposes.