For research use only
| Cat No. | ABC-TC0689 |
| Product Type | Human Gastric Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Product Code | MKN74; MKN 74 |
MKN-74 derived from tubular adenocarcinoma express SNCG and exhibit intestinal features. They are used in metastasis and tumor progression studies.
MKN-74 is a human adenocarcinoma cancer cell line established from a moderately differentiated tubular adenocarcinoma of the stomach in a 37-year-old Japanese male. These cells exhibit an epithelial morphology, grow adherently, and retain many characteristics of intestinal-type gastric cancer. This cell line is known for moderate differentiation and expresses relevant markers such as E-cadherin (CDH1) and CEA. MKN-74 cells harbor mutations in TP53, a common tumor suppressor gene altered in gastric cancers. MKN-74 expresses the synuclein γ (SNCG) gene, overexpression of SNCG is associated with enhanced proliferation and metastatic capacity in gastric cancer cells. These cells are tumorigenic in nude mice, making them suitable for both in vitro and in vivo cancer studies. Their stable growth and phenotypic resemblance to human gastric tumors provide a reliable model for studying gastric cancer pathogenesis and therapy.
| Product Code | MKN74; MKN 74 |
| Species | Human |
| Cat.No | ABC-TC0689 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Gastric Cancer Cell Lines |
MKN-74 cells provide a robust model to study the effects of growth factors on gastric cancer cell proliferation and apoptosis, elucidating key molecular pathways. They are essential for investigating mechanisms driving malignancy and poor prognosis, aiding in the identification of therapeutic targets and prognostic markers. Additionally, MKN-74 cells facilitate research on drug resistance by enabling evaluation of anticancer agents and exploration of resistance mechanisms to improve treatment strategies.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
