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| Product Code | Mkl-1; MKL1 |
| Species | Human |
| Cat.No | ABC-TC0684 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Skin Cancer Cell Lines |
The MKL-1 cell line, derived from a nodal metastasis in a 26-year-old patient with neuroendocrine skin carcinoma, exhibits distinct characteristics in its growth pattern. The cells manifest as irregularly outlined, loosely packed floating aggregates, devoid of central necrosis. MKL-1 is hyperdiploid. In xenograft studies, inoculation of 2×10^7 MKL-1 cells subcutaneously in nude mice results in tumor formation within 4 to 6 weeks. Notably, these xenografts closely resemble the morphological features of the original skin primary and the nodal metastasis.
Furthermore, gel electrophoresis and immunoblotting analysis reveal the abundance of the small neurofilament polypeptide in MKL-1 cells. This comprehensive characterization underscores the utility of MKL-1 as a valuable model for investigating neuroendocrine skin carcinoma and its potential applications in biomedical research.
Why choose MKL-1 from AcceGen?
A pinnacle of quality and reliability in cell culture models. Our commitment to excellence is reflected in the meticulous quality control (QC) tests performed on MKL-1 cells to ensure their robust utility in your scientific endeavors.
Key Quality Control Measures:
Sterility Assurance
MKL-1 cells are rigorously tested for sterility, ensuring the absence of bacterial, fungal, and
mycoplasma contamination. PCR analysis is employed to confirm the cleanliness of the culture. Furthermore, the cells are verified to be free from human pathogens.
Viability Excellence
Your experiments demand optimal viability. MKL-1 cells boast a post-thaw viability exceeding 95%, providing a strong and resilient foundation for your biomedical studies.
Identity Verification with STR Analysis
Upholding the highest standards of authenticity, we conduct Short Tandem Repeat (STR) analysis using 16 probes, encompassing 15 STR loci plus Amelogenin. This rigorous identity check ensures the unequivocal authenticity of the MKL-1 cell line.
Growth Characteristics Defined
MKL-1 cells exhibit growth characteristics meticulously assessed based on morphology and immunocytochemistry of multiple undifferentiation markers. This comprehensive evaluation ensures that MKL-1 maintains its intended properties for your research needs.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
MKL-1 cell line serves as a valuable tool in various scientific research applications. Here are some potential applications of the MKL-1 cell line in science research:
Cancer Research
MKL-1 cells, being derived from a neuroendocrine skin carcinoma, are particularly relevant for cancer research. Scientists can use this cell line to study the molecular and cellular mechanisms underlying the development, progression, and behavior of neuroendocrine skin carcinoma.
Drug Discovery and Testing
MKL-1 cells can be employed in drug discovery and testing studies to evaluate the efficacy of potential therapeutic agents against neuroendocrine skin carcinoma. This includes assessing the impact of chemotherapy agents, targeted therapies, or experimental compounds on the growth and behavior of MKL-1 cells.
Tumor Biology Studies
Researchers can use MKL-1 cells to investigate various aspects of tumor biology, including tumor size, response to different treatment modalities, and the expression of specific markers associated with neuroendocrine tumors.
Molecular and Cellular Biology Studies
The MKL-1 cell line provides a model system for studying molecular and cellular events associated with neuroendocrine skin carcinoma. This may involve examining gene expression patterns, signaling pathways, and cellular responses to external stimuli.
Immunocytochemistry and Marker Expression
MKL-1 cells can be utilized in immunocytochemistry studies to assess the expression of specific markers associated with undifferentiated cells. This allows researchers to characterize the identity and differentiation state of the cells.
Multistage Carcinogenesis Research
Given its origin and characteristics, MKL-1 cells can contribute to studies focused on multistage carcinogenesis. Researchers can explore the cellular changes and events that occur during different stages of tumor development.
Modeling Metastasis
As MKL-1 is derived from a nodal metastasis, it can be used to study the processes and factors involved in metastasis formation. This is crucial for understanding the spread of cancer cells to different parts of the body.
