MicroRNA: mmu-miR-135b-5p Accession Number: MIMAT0000612 Mature Sequence: UAUGGCUUUUCAUUCCUAUGUGA mmu-miR-135b-5p are small non-coding RNAs of 20-22 nucleotides, typically excised from 60-110 nucleotide foldback RNA precursor structures. miRNAs are involved in crucial biological processes, including development, differentiation, apoptosis, and proliferation, through imperfect pairing with target messenger RNAs (mRNAs) of protein-coding genes and the transcriptional or post-transcriptional regulation […]
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*cover all human, mouse, and rat miRNAs listed in miRBase
*higher stability/inhibitory effects in vivo and in vitro
*more stable, easier to pass the cell membrane and tissue gap
*purified and ready-to transfect cells/be administered by injection, inhalation, feeding
*less reagent use amount with longer effect time
Description
Mmu-miR-135b-5p is a specific type of microRNA (miRNA) found in mice. MicroRNAs are small, single-stranded RNA molecules that play important roles in the post-transcriptional regulation of gene expression. Mmu-miR-135b-5p is derived from the precursor miRNA mmu-miR-135b, and its mature sequence is typically around 22 nucleotides in length.
MicroRNAs like mmu-miR-135b-5p function by binding to complementary sequences in the 3′ untranslated region (UTR) of target messenger RNA (mRNA) molecules, leading to the inhibition of protein translation or degradation of the mRNA. This regulatory process allows microRNAs to control the expression of genes involved in various biological processes, including development, differentiation, proliferation, apoptosis, and metabolism.
The specific targets and functions of mmu-miR-135b-5p may vary depending on the cellular context and physiological conditions. Research studies have implicated mmu-miR-135b-5p in various biological processes and disease pathways, including cancer, inflammation, neuronal development, and metabolic disorders. Additionally, dysregulation of mmu-miR-135b-5p expression has been associated with certain diseases and pathological conditions, highlighting its potential importance as a diagnostic or therapeutic target
Why choose MIRacle™ mmu-miR-135b-5p miRNA Agomir/Antagomir from AcceGen?
Synthesis Excellence
AcceGen boasts extensive experience in synthesizing MicroRNA Agomir/Antagomir, covering human, mouse, and rat miRNAs listed in the current miRBase.
Extended Stability
Our miRNA Agomir and Antagomir products outshine standard mimics and inhibitors, demonstrating enhanced resistance to degradation. Experience sustained effects lasting from a minimum of 1 week up to an impressive 5-6 weeks.
Versatile Applications
Employ these products seamlessly in in vitro or in vivo miRNA functional studies, unlocking new dimensions in your research endeavors.
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Citation
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Application
FOR RESEARCH USE ONLY
The role and functions of mmu-miR-135b-5p would need to be explored in the context of specific biological processes or diseases, as different microRNAs can have diverse roles in various cellular functions, including development, metabolism, and disease pathways. Here are some potential applications:
Functional Studies
Investigating Gene Regulation: Studying the interactions between mmu-miR-135b-5p and specific target messenger RNAs (mRNAs) helps unravel the regulatory networks involved in gene expression.
Cellular Processes
Assessing the impact of mmu-miR-135b-5p on cellular functions, such as development, differentiation, apoptosis, and proliferation.
Cancer Studies
Exploring the involvement of mmu-miR-135b-5p in cancer-related pathways, considering its role in cell growth, differentiation, and apoptosis. This can contribute to cancer diagnostics and therapeutic development.
Cardiovascular Research
Investigating the potential role of mmu-miR-135b-5p in cardiovascular diseases, as microRNAs often participate in the regulation of cardiovascular-related genes.
Therapeutic Development:
Target for Therapeutics
Understanding the functions of mmu-miR-135b-5p may identify it as a potential therapeutic target for modulating specific cellular processes or treating diseases.
miRNA-based Therapies:
Exploring the use of mmu-miR-135b-5p mimics or inhibitors in miRNA-based therapies for diseases where its dysregulation is implicated.
In Vivo and In Vitro Studies
Animal Models: Using mmu-miR-135b-5p Agomir/Antagomir in mouse models to investigate the in vivo effects, providing insights into the physiological relevance of this miRNA.
Cell Culture Experiment
Employing mmu-miR-135b-5p in in vitro experiments to elucidate its role in specific cellular pathways or processes.
Molecular Biology Techniques
Reporter Assays: Utilizing mmu-miR-135b-5p in reporter assays to validate its interactions with specific target genes.
PCR and Western Blot Analysis: Investigating changes in mRNA and protein expression levels in response to mmu-miR-135b-5p modulation.
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