MIN-6
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The MIN-6 cell line is a mouse pancreatic beta cell line derived from insulinomas in transgenic mice through the targeted expression of the simian virus 40 T antigen gene. These cells closely resemble pancreatic beta cells in terms of their morphology and ability to produce insulin and T antigen. MIN-6 cells demonstrate glucose-dependent insulin secretion similar to normal mouse islet cells and exhibit high levels of liver-type glucose transporter mRNA. However, recent research suggests that MIN-6 is not a pure beta cell line but rather a mixed cell line that also secretes glucagon, somatostatin, and ghrelin. Molecular analysis reveals the presence of various mRNAs associated with insulin I and II, proglucagon, somatostatin, pancreatic polypeptide (PP), and ghrelin. Furthermore, immunofluorescence imaging reveals the coexistence of insulin-positive cells with double-positive cells expressing insulin and either glucagon or somatostatin within the MIN-6 cell population.
Why choose MIN-6 from AcceGen?
MIN-6 cells from AcceGen are an excellent choice due to their high quality and viability. These cells are provided in a sterile condition and undergo rigorous quality control measures, ensuring reliable and consistent results for research and experimental purposes.
| Product Code | Min6; MIN-6; Mouse INsulinoma 6 |
| Species | Mouse |
| Cat.No | ABC-TC234S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | β Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Pancreas Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
With the ability to regulate insulin secretion in response to glucose concentrations, the MIN-6 cell line holds significant applications in studying the molecular mechanisms of beta cell regulation. It serves as a valuable model for investigating pancreatic islet development, cell differentiation, and overall islet function. Researchers can utilize MIN-6 cells to gain insights into the intricate processes involved in insulin secretion and explore potential therapeutic strategies for conditions related to beta cell dysfunction, such as diabetes.
