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| Product Code | Min6; MIN-6; Mouse INsulinoma 6 |
| Species | Mouse |
| Cat.No | ABC-TC234S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | β Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Pancreas Cancer Cell Lines |
The MIN-6 cell line is a mouse pancreatic beta cell line derived from insulinomas in transgenic mice through the targeted expression of the simian virus 40 T antigen gene. These cells closely resemble pancreatic beta cells in terms of their morphology and ability to produce insulin and T antigen. MIN-6 cells demonstrate glucose-dependent insulin secretion similar to normal mouse islet cells and exhibit high levels of liver-type glucose transporter mRNA. However, recent research suggests that MIN-6 is not a pure beta cell line but rather a mixed cell line that also secretes glucagon, somatostatin, and ghrelin. Molecular analysis reveals the presence of various mRNAs associated with insulin I and II, proglucagon, somatostatin, pancreatic polypeptide (PP), and ghrelin. Furthermore, immunofluorescence imaging reveals the coexistence of insulin-positive cells with double-positive cells expressing insulin and either glucagon or somatostatin within the MIN-6 cell population.
Why choose MIN-6 from AcceGen?
MIN-6 cells from AcceGen are an excellent choice due to their high quality and viability. These cells are provided in a sterile condition and undergo rigorous quality control measures, ensuring reliable and consistent results for research and experimental purposes.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
With the ability to regulate insulin secretion in response to glucose concentrations, the MIN-6 cell line holds significant applications in studying the molecular mechanisms of beta cell regulation. It serves as a valuable model for investigating pancreatic islet development, cell differentiation, and overall islet function. Researchers can utilize MIN-6 cells to gain insights into the intricate processes involved in insulin secretion and explore potential therapeutic strategies for conditions related to beta cell dysfunction, such as diabetes.
