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MCF-12A, a non-malignant breast cancer cell line, was extracted from the mammary gland of a 60-year-old White female patient who had fibrocystic breast disease with intraductal hyperplasia.
Derived through a reduction mammoplasty procedure from a nulliparous individual, these cells predominantly exhibit an epithelial morphology. In culture, they adhere in small patches, gradually forming domes as they reach confluence. These patches, varying in size, cluster more tightly with higher cell density. Notably, the MCF-12A cell line often shows the presence of floaters and debris. This cell line is a valuable resource for research related to non-malignant breast cancer.
Why choose MCF-12A from AcceGen?
MCF-12A cell line boasts high quality and viability, ensuring reliable research outcomes. It is maintained in sterile conditions, rigorously tested for mycoplasma contamination, and its identity is verified through STR analysis. The cells are carefully cryopreserved by experienced operators, and stringent quality control measures are consistently applied to maintain their integrity and reliability in experimental settings.
| Product Code | MCF12A |
| Species | Human |
| Cat.No | ABC-TC0639 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Skin Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
MCF-12A cell line finds versatile applications in breast cancer research, enabling the exploration of genes’ roles in breast cancer pathophysiology and the identification of genomic and transcriptional features in breast cancer cells. These insights aid in predicting responses to targeted therapies and other physiological changes. Moreover, MCF-12A is valuable for 3D culture studies, facilitating investigations into proliferation, signaling protein expression, and gene expression. It also highlights consistent differences in genes encoding signal transduction proteins when studying tumor cells within 3D microenvironments, offering critical insights into breast cancer biology.
