LS-180
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LS-180 is an epithelial cell line derived from the colon of a 58-year-old white female patient with Dukes type B adenocarcinoma. These cells secrete CEA and mucin and exhibit tumorigenic properties in nude mice. The stemline karyotype of LS-180 cells is 45, with approximately 2.2 percent of cells being tetraploid-like, showing t(X;5) (q12;q31). In continuous culture, LS-180 cells grow as a monolayer. Notably, they contain both aromatic hydrocarbon receptor and cytosolic receptor. Additionally, exposure to specific compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3-methylcholanthrene (MC), or benz[a]anthracene can significantly induce CYP1A2 in LS-180 cells.
Why choose LS-180 from AcceGen?
LS-180 cell line exhibits high quality and viability, maintained in a sterile environment. The cell line undergoes advanced cryopreservation techniques to ensure preservation and long-term storage. Its quality is upheld through rigorous quality control measures, making it a reliable and valuable resource for various research applications.
| Product Code | LS-180; LS 180 |
| Species | Human |
| Cat.No | ABC-TC0605 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Colorectal Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
LS-180 cell line serves as a valuable resource in the investigation of intestinal transporter regulation. Additionally, it constitutes a strong model for conducting mechanistic studies on AHR-regulated CYP1A2 expression. Moreover, LS-180 is recognized as an exceptional tool for studying the pregnane X receptor. Its multiple applications make LS-180 a crucial asset in advancing research in these specific areas of interest.
