LP-1
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LP-1, a cell line derived from a patient with IgG-lambda myeloma, displays characteristics reminiscent of immature plasma cells. While it secretes IgG-lambda chains, LP-1 cells exhibit an intermediate membrane phenotype between late B lymphocytes and plasma cells. When exposed to 12-O-tetradecanoylphorbol-13-acetate (TPA) or pokeweed mitogen (PWM), these cells manifest surface markers and ultrastructural features which are typical of mature plasma cells, with no impact on their ability to proliferate. Molecular analysis of LP-1 demonstrates an increased expression of the c-myc protooncogene and the presence of transcripts with abnormal sizes. Furthermore, LP-1 harbors the t(4;14) translocation.
Why choose LP-1 from AcceGen?
LP-1 cells from AcceGen possess several key features that make them ideal for research purposes. They are maintained in sterile conditions, ensuring their purity and minimizing the risk of contamination by mycoplasma, as confirmed through rigorous PCR-based and luminescence-based mycoplasma assays. LP-1 cells can be incubated under standard and optimal conditions, with regular visual inspections carried out to detect any bacterial or fungal presence. Additionally, LP-1 cells are cryopreserved using advanced techniques, allowing for long-term storage and future use.
| Product Code | LP1 |
| Species | Human |
| Cat.No | ABC-TC516S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Blood |
| Disease | Multiple Myeloma |
| Storage | Liquid Nitrogen |
| Product Type | Human Myeloma Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The LP-1 cell line holds significant applications in research. It serves as a valuable model for investigating B-cell maturation, offering insights into unconventional mechanisms of c-myc activation. Moreover, LP-1 cells have the potential to be utilized in the creation of human hybridomas, making them an attractive candidate for generating hybrid cell lines with the ability to produce monoclonal antibodies. The unique attributes of LP-1 cells contribute to their importance in advancing our understanding of B-cell development and their practical applications in antibody production.
