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| Product Code | LP1 |
| Species | Human |
| Cat.No | ABC-TC516S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Blood |
| Disease | Multiple Myeloma |
| Storage | Liquid Nitrogen |
| Product Type | Human Myeloma Cell Lines |
LP-1 is an immortalized tumor cell line derived from the peripheral blood of a 56-year-old female patient diagnosed with IgG-lambda multiple myeloma in leukemic transformation. The cell line was established in 1986 . LP-1 cells exhibit characteristics reminiscent of immature plasma cells, including an intermediate membrane phenotype between late B lymphocytes and plasma cells. They secrete IgG-lambda chains and, upon exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA) or pokeweed mitogen (PWM), display surface markers and ultrastructural features typical of mature plasma cells, without affecting their proliferation rate .LP-1 cells are cultured in suspension and exhibit typical lymphoblastoid morphology. They are maintained under standard conditions at 37°C in a humidified atmosphere with 5% CO₂.Cytogenetic analysis reveals that LP-1 harbors the t(4;14)(p16.3;q32) translocation, a hallmark of high-risk myeloma, and exhibits overexpression of the c-myc protooncogene, including transcripts of abnormal sizes. Regarding viral status, LP-1 is confirmed to be Epstein-Barr virus (EBV)-negative.
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The LP-1 cell line has important applications in research. It is a useful model for studying B-cell maturation, offering insights into unconventional mechanisms of c-myc activation. Moreover, LP-1 cells have the potential to be utilized in the creation of human hybridomas, making them ideal for producing monoclonal antibody-secreting hybrid cell lines. The unique attributes of LP-1 cells contribute to their importance in advancing our understanding of B-cell development and their practical applications in antibody production.
