KP-4
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KP-4 is a human pancreatic ductal cell carcinoma cell line derived from human ascites. KP-4 secretes parathyroid hormone-related peptide (PTHrP), and it can be a useful system to study the regulation of PTHrP production and its pathophysiological roles. KP-4 is a highly metastatic cell line compared to other pancreatic cancer cell lines, and it can metastasize to other tissues, such as liver, lung, etc. Although it is thought to be epithelial-like in morphology, KP-4 presents a low E-cadherin and high vimentin mRNA levels under 2D culture conditions.
Why Choose KP-4 from AcceGen?
AcceGen provides customers a high-quality KP-4 cell line using our special and advanced techniques. In the production of KP-4, AcceGen professionally controls each step to keep a stable and sterile operation for a healthy cell state. With our strict regulations and rules for quality control, we offer every customer the best KP-4.
| Product Code | KP 4; KP4 |
| Species | Human |
| Cat.No | ABC-TC0544 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Pancreas Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
KP-4 can be used to investigate that how cancer cell escapes apoptosis. It was found that PI3K inhibitor can inactivate Akt, resulting in inhibition of cell proliferation in human pancreatic ductal carcinoma cell lines, PSN-1[a], PANC-1[b], and KP-4, and cell cycle arrested in the G1 phase with the PI3K inhibitor. Subsequent studies, using KP-4 cells, can give more details to indicate if PI3K-AKT signaling pathway supports cell proliferation in human pancreatic ductal cell carcinoma cells. Otherwise, KP-4 can be applied in the field of identifying mutants and essential gene profiles of human pancreatic carcinoma for screening target genes and developing RNA drugs.
