KM12SM
1
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KM12SM is a human colon cancer cell line, and the cell morphology is epithelial-like. Colon cancer is one of the most common malignancies in the digestive tract and progresses from local adenomas in the intestinal epithelium to invasive carcinomas that usually metastasize to the liver. Liver metastasis in colorectal cancer is the major cause of cancer-related deaths. KM12SM is highly metastatic. A study showed that when metastatic KM12SM colorectal cancer cells were injected into the spleen and tail vein of mice, the cells metastasized to the liver. Besides, KM12SM cells were highly dependent on mitochondrial oxidative phosphorylation. Studies on colorectal metastatic cancer KM12SM cells showed that three proteins, EFNA3, CD137L/TNFSF9 and SOSTDC1, play key roles in the liver homing for metastases.
Why choose KM12SM from AcceGen?
KM12SM cell line from AcceGen is incubated under optimal conditions and cryopreserved by skilled operators. Cells are cultured in medium of DMEM with 10%FBS and 1% P/S, and maintained at 37℃ with 5% CO2. They are high viability and the number of cells is 1×10⁶cells/vial.
| Product Code | KM12SM; KM12 SM |
| Species | Human |
| Cat.No | ABC-TC0512 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
KM12SM can be used to compare sensitivity to natural killer (NK) cell-mediated cytotoxicity to determine resistance to NK cell-mediated lysis. The in vitro cultured human colon cancer cell line KM12SM can also be used to explore the mechanisms and pathways that promote cell proliferation and invasion, such as the regulation and mechanism of action of Phospholipase D (PLD) in tumor progression using cell scratch assays. In addition, due to its liver metastatic ability, the cell line can also be used to study liver homing and late stages of metastasis. Biological studies on colorectal cancer metastasis can help to identify diagnostic/prognostic biomarkers or markers relevant to potential drug targets.
