KIF5B-RET(V804E) BaF3 Cell Line

The KIF5B-RET fusion protein is a protein produced by the fusion of the KIF5B (kinesin family member 5B) and RET (Rearranged during Transfection) genes. This fusion protein is found in certain tumors, particularly lung cancer and thyroid cancer. The KIF5B-RET fusion protein possesses kinase activity, which can activate cell signaling pathways, promoting tumor growth and metastasis. Therefore, the KIF5B-RET fusion protein is considered a key driver of tumors and a potential therapeutic target. BA/F3 cells are IL-3 (interleukin-3) dependent precursor B cells, and some protein kinases can replace IL-3 to promote IL-3-dependent growth of Ba/F3 cells. Inhibitors are then used to antagonize this effect, allowing for the study of kinase inhibitors.