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The Kasumi-1 cell line is derived from an Asian male patient with acute myeloblastic leukemia and exhibits properties of myeloid and macrophage lineages. These cells express myeloperoxidase and carry an 8;21 chromosome translocation. In culture, Kasumi-1 cells respond to interleukin-3 (IL-3),
IL-6, granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage CSF (GM-CSF), but not to IL-1 or IL-5. They do not undergo granulocytic or eosinophilic maturation when exposed to dimethyl sulfoxide, G-CSF, or IL-5. However, the addition of a phorbol ester induces a macrophage-like differentiation in these cells. Furthermore, their proliferation is inhibited by 1,25S-(OH)2-16,23-diene-26-F3-10-nor D3.
Why choose Kasumi-1 from AcceGen?
Kasumi-1 cells from AcceGen are characterized by their exceptional viability and quality, cultivated under expert supervision in optimal conditions. These cells are maintained in a sterile environment with rigorous daily monitoring to guarantee the absence of bacterial and fungal contamination. Additionally, PCR testing confirms their negative status for mycoplasma and various viruses, including EBV, HBV, HCV, HHV-8, HIV-1, HIV-2, HTLV-1/2, MLV, and SMRV, ensuring their suitability for research and experimentation.
| Product Code | KASUMI-1; Kasumi 1; KASUMI1; Kasumi1 |
| Species | Human |
| Cat.No | ABC-TC0492 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Myeloblast |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Blood |
| Disease | Acute Myeloid Leukemia |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The Kasumi-1 cell line has diverse applications in scientific research, including 3D cell culture, immune system disorder investigations, and immunology studies. Notably, it serves as a valuable tool for unraveling the pathophysiology of acute myeloid leukemia (AML) with t(8;21) translocation. Kasumi-1’s crucial role in experimental models with this translocation makes it a representative example of leukemia cell lines, facilitating in-depth studies. Furthermore, it is instrumental in exploring altered KIT signal transduction pathways in AML with core binding factor rearrangements and serves as a useful platform for pharmacological therapeutic targeting in this context.
