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| Product Code | KARPAS-299; Karpas 299; KARPAS 299; Karpas299; KARPAS299; K299 |
| Species | Human |
| Cat.No | ABC-TC5559 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphoblastoid |
| Shipping Info | Dry ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lymphoma |
| Disease | Anaplastic Large Cell Lymphoma |
| Storage | Liquid Nitrogen |
| Product Type | Human Lymphoma Cell Lines |
Karpas 299 is a human T cell lymphoma cell line that originated from a 25-year-old man diagnosed with T cell non-Hodgkin’s lymphoma in 1986. This cell line is now categorized as CD30+ anaplastic large cell lymphoma (ALCL) and carries the NPM-ALK fusion gene. Notably, Karpas 299 cells exhibit a reciprocal translocation between chromosomes 2 and 5, 
a phenomenon previously observed in cases of “malignant histiocytosis”. These cells have been extensively characterized using immunocytochemical analysis with monoclonal antibodies and DNA hybridization with probes for Ig and T-cell receptor genes, confirming their T-cell origin. Karpas 299 cell line expresses markers indicative of T-cell lymphoma, including CD2, CD3, and CD7.
Why choose KARPAS 299 from AcceGen?
KARPAS 299 cells from AcceGen exhibit exceptional characteristics, boasting high viability and quality. These cells are maintained in a sterile environment and cultured under optimal conditions, ensuring their vitality. They are cryopreserved using advanced techniques to preserve their integrity, and their identity is confirmed through STR analysis, reflecting AcceGen’s commitment to rigorous quality control standards.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The Karpas 299 cell line serves as a valuable model for in-depth analysis of the 2;5 translocation at the molecular level, offering insights into the underlying mechanisms of this genetic event. Additionally, it plays a crucial role in the comprehensive characterization of Ki-positive large cell lymphomas of the non-Hodgkin’s type. This cell line has found widespread application in the study of lymphoma biology, facilitating research into the molecular pathways driving lymphoma development and progression. Furthermore, it has been instrumental in identifying potential therapeutic targets, thereby contributing significantly to the advancement of lymphoma treatment strategies.
