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IST MES2 is a human malignant pleural mesothelioma cell line with an epithelioid phenotype. The cells are spindle-shaped in culture and form a cobblestone-like pattern when confluent. Despite this, IST MES2 cells are unable to grow in nude mice. The cell line exhibits hypodiploid karyology and carries a p53 mutation. In culture, IST MES2 cells enter the exponential growth phase within 4-7 days after plating, with a doubling time ranging from 37-87 hours. The IST MES2 cell line does not respond to insulin-like growth factor-I stimulation in terms of cellular proliferation. Furthermore, the cell line is capable of releasing a constitutively high amount of IL-6 and variable levels of TGF-beta. While no spontaneous TNF-alpha secretion is detectable in the supernatant of cell lines, stimulation with LPS reveals their ability to release substantial amounts of TNF-alpha.
Why choose IST MES2 from AcceGen?
The IST MES2 cell line is distinguished by its exceptional features, including high quality and viability. It is maintained under strict sterile conditions and incubated in an environment optimized for optimal growth. Rigorous quality control measures are implemented to guarantee its authenticity and reliability, making it a trusted and valuable resource for research and experimentation in the field of malignant pleural mesothelioma.
| Product Code | IST-MES2; IST-MES-2; ISTMES2; IstMes2 |
| Species | Human |
| Cat.No | ABC-TC0459 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Pleural Epithelioid Mesothelioma |
| Biosafety Level | 2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The IST MES2 cell line holds significant applications in various aspects of malignant pleural mesothelioma (MPM) research. It serves as an essential tool to highlight the biology of MPM and evaluate the efficacy of new antiproliferative compounds. Additionally, IST MES2 is a valuable cell model for identifying novel targets for innovative pharmacological therapy against MPM. Moreover, it aids in proposing molecular pathways for potential pharmacological targets, paving the way for personalized medicine in MPM patients. Furthermore, the cell line allows investigation into the development of resistance to receptor-induced cell death in malignant mesothelial cells, providing insights into therapeutic challenges and potential solutions for MPM treatment.
