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Immortalized Mouse Microglial Cell Line | ||||
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| Product Name | Immortalized Mouse Microglial Cell Line | |||
| Price | Get Quote | |||
| Cat.No | ABI-TC034D | Species | Mouse | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Immortalised microglial cell line (IMG) isolated from the brains of adult mice.Microglia cells share functional similarities with macrophages, and are thought to act as the primary immune cells of the central nervous system (CNS). They monitor their microenviornment and become activated upon detection of abnormal and/or offensive signals. Activated microglia have been found in inflammatory conditions such as brain/spinal cord injury, ischemic strokes, infections and neurodegenerative diseases. Recent findings indicate that microglia are also involved in learning and memory by regulating synaptic plasticity. | |||
| Disease | Normal | |||
| Source Organ | Brain | |||
| Recommended Medium And Supplement | ABI-TM034D Mouse Microglial Cell Line Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | For research use only | |||
| Morphology | Ramified/Amoeboid | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Microglial | |||
| Growth Mode | Adherent | |||
| Product Type | Immortalized Cell Line | |||
| Product Image |  | |||
Frequently Asked Questions
What are the key features of the Immortalized Mouse Microglial Cell Line?
The Immortalized Mouse Microglial Cell Line (IMG) expresses key markers such as F4/80 and CD11b, and does not express neuronal or astrocyte markers like NeuN and GFAP. These cells can robustly respond to inflammatory signals, displaying M1/M2 polarization, and are capable of phagocytosing foreign particles and misfolded proteins, such as amyloid-beta peptide.
What are the Immortalized Mouse Microglial Cell Line used for in research?
These cells are used to study the mechanisms of drug action, drug efficacy in relation to M1/M2 polarization, and inflammatory responses in the central nervous system. They can be induced to adopt pro- or anti-inflammatory phenotypes, making them valuable for exploring cellular responses in various disease models such as brain/spinal cord injury, ischemic strokes, infections, and neurodegenerative diseases.
What is the source and morphology of these microglial cells?
These microglial cells are derived from the brains of 8-week-old C57BL/6J mice. They exhibit both ramified and amoeboid morphologies.
How should these cells be cultured, stored, and shipped to maintain their viability?
These cells should be cultured in DMEM supplemented with 4.5g/L glucose, glutamate, 10% fetal bovine serum (FBS), and 1% penicillin/streptomycin. For long-term storage, the cells should be cryopreserved in growth medium supplemented with 10% DMSO and stored in liquid nitrogen. They are shipped on dry ice to maintain viability.
What are the unique contributions of microglia to neurological research?
Microglia are the primary immune cells of the central nervous system (CNS) and are pivotal in monitoring and responding to pathological conditions within the brain. They play critical roles in inflammatory conditions, contribute to synaptic plasticity, and are involved in processes related to learning and memory. These functional capabilities make them crucial for studies on brain dynamics and pathology, particularly in relation to neurodegenerative diseases and cognitive functions.
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