Our immortalized mouse microglia are mouse microglia cells transformed using SV40 T antigen, allowing them to retain their properties indefinitely. These specialized macrophage cells are primarily located in the brain and spinal cord, serving as the first line of defense in the nervous system. Immortalized mouse microglia exhibit similar characteristics to primary microglia cells, expressing CD11b and Iba1, as confirmed by immunocytochemistry microphotographs and QPCR analysis. Moreover, they also demonstrate the expression of microglia-specific markers P2RY12 and TGFβR at the transcript level. When exposed to LPS treatment, these immortalized cells respond by releasing pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Inquiring Immortalized Mouse Microglia
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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research
