Microglia are specialized cells that reside in the brain parenchyma and play a pivotal role in immune defense and inflammation in the central nervous system (CNS). They act as regulators of brain homeostasis and interact with surrounding neurons and non-neuronal cells. They phagocytose cellular debris, apoptotic cells, and invading pathogens. Microglia stay in a ramified “resting” state until stimulated by abnormal activities such as inflammation, infection, or trauma. Activated microglia cells are capable of secreting cytokines, chemokines, growth factors and reactive oxygen species that trigger signal transduction responsible for the inflammatory response. Despite the immune function, microglia also facilitate cerebral processes such as synaptic architecture and neurogenesis. Growing evidence has suggested microglia function as a key mediator in the progression of neurodegeneration and inflammatory CNS disorders.
Why choose Immortalized Human Microglia (SV40 cell line) from AcceGen?
Immortalized Human Microglia (SV40 cell line) are derived from fully consented healthy human brains using AcceGen’s advanced technology. Cells are immortalized through serial passaging and transduction with recombinant lentiviruses carrying SV40 Large T antigen. Cells are cryopreserved with each vial containing more than 5×10^5 cells in 1ml volume. Immortalized Human Microglia (SV40 cell line) are quality tested with microglia markers TREM2, IBA1(AIF-1), CD68 and NGF by RT-PCR.
