Immortalized Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis
BSL
1
163
Human Rheumatoid Arthritis synoviocytes (HRAS) were isolated from human rheumatoid arthritis synovium tissue and SV40-HRAS were selected from HRAS infected with SV40.
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Immortalized cell lines, generated from primary cells, have an extended lifespan and provide a continuous and stable cell source for experimental purposes. Immortalized Human Fibroblast-Like Synoviocytes (FLS) in the context of rheumatoid arthritis (RA) refer to a type of cell found in the synovium, which is the tissue lining the joints. Immortalized Fibroblast-like synoviocytes are a key cell type involved in the pathogenesis of RA. Rheumatoid arthritis (RA) affects approximately 1% of the adult population1,2. Despite being a systemic disease, the primary clinical manifestations are synovitis and joint destruction. RA fibroblast-like synoviocytes (RA-FLS) play a central role in initiation and persistence of both synovitis and joint damage3,4.
Why choose Immortalized Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis from AcceGen?
Rest assured, immortailized FLS cells undergo thorough testing to ensure premium quality. Negative results for mycoplasma, bacteria, yeast, and fungi guarantee the integrity of your experiments. Achieve unparalleled results with over 95% post-thaw viability, setting the stage for robust cell line performance. Witness optimal growth characteristics, meticulously validated through morphology assessments and immunocytochemistry of multiple undifferentiation markers. Immortalized Human FLS cell line is chosen for a seamless blend of reliability and excellence in advancing RA research.
Species
Human
Cat.No
ABI-H0004X
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category
Immortalized Cell Lines
Size/Quantity
1 vial
Cell Type
Fibroblast-Like
Shipping Info
Dry Ice
Growth Conditions
37 ℃, 5% CO2
Source Organ
Synovium
Disease
Rheumatoid Arthritis
Biosafety Level
1
Storage
Liquid Nitrogen
Product Type
Immortalized Cell Line
Citation
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Application
FOR RESEARCH USE ONLY
Immortalized Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis can be used to investigate the behavior of synovial cells in the context of rheumatoid arthritis, including their responses to inflammatory stimuli, production of cytokines and other signaling molecules, and potential involvement in joint damage. Studying these cells helps researchers gain insights into the disease mechanisms and may contribute to the development of targeted therapies for rheumatoid arthritis.
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