Immortalized Human Fibroblast-Like Synoviocytes are derived by immortalizing primary human synoviocytes obtained from healthy synovial tissue through the introduction of SV40 Large T antigen. As the predominant cell type in normal synovial tissue, Human Fibroblast-Like Synoviocytes constitute the synovial lining layer, playing a crucial role in joint health. Responsible for synthesizing synovial fluid, these synoviocytes facilitate absorption in the joint cavity and regulate blood/synovial fluid exchanges. Notably, they exhibit characteristics such as anchorage-independent growth and the secretion of various effector molecules, contributing to inflammation and joint destruction.
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