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Immortalized Human Endometrial Epithelial Cells

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Immortalized Human Endometrial Epithelial Cells have been developed by immortalizing primary Human Endometrial Epithelial Cells with SV40 Large T antigen. Each vial of Immortalized Human Endometrial Epithelial Cells contains more than 500.000 viable cells.
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Home | Immortalized Cell Lines | Immortalized Human Endometrial Epithelial Cells

Human endometrial epithelial cells are isolated from human endometrial tissue and then immortalized with SV40 large T antigen, resulting in an immortalized cell line. In immunocytochemistry and immunocytofluorescent assays, the endometrial epithelial cells show positive staining for epithelial cell adhesion molecule (EpCam) and stage-specific embryonic antigen-1 (SSEA-1), while CD13 is not expressed. Immunoblotting analysis reveals the presence of epithelial cell markers in endometrial epithelial cells, such as Keratin 17, 19, and EpCam, as well as stem cell markers OCT3/4. With each passage of endometrial epithelial cells, the expression of Sry-box-2 (SOX2), P63, c-Myc, and CD117 (c-kit) decreases. Endometrial epithelial cells demonstrate the potential to differentiate into stromal-like cells in the air-liquid interface (ALI) state and form spheroids.

 

Why choose Immortalized Human Endometrial Epithelial Cells from AcceGen?

AcceGen has advanced immortalization techniques to confer excellent immortality to human endometrial epithelial cells. We adhere to rigorous standards for culture and quality control. In addition to conventional test projects, such as assessing cell morphology, cell viability, and sterility, we also thoroughly examine telomerase activity in immortalized cell products.

Species

Human
Cat.No

ABC-H0045X
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Endometrium
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Line

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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Application

  • FOR RESEARCH USE ONLY

  • Through research on human endometrial epithelial cells, their role in the repair and regeneration of the human endometrium can be investigated. These cells offer a valuable tool to recapitulate the pathogenesis of various endometrium-related carcinomas, such as ovarian clear cell carcinoma, uterine endometrioid carcinoma, and ovarian endometrioid carcinoma, by studying the interactions between normal cells and their malignant counterparts. Furthermore, as genomic imbalances are predominantly detected in endometriotic stroma and epithelia, immortalized human endometrial epithelial cells can contribute to the study of endometriosis pathogenesis. The utilization of these cells provides insights into the physiological and pathological processes of the endometrium, contributing to advancements in our understanding of these conditions and potential therapeutic approaches.

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  • HumanEndothelial (12)

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