Immortalized Human Brain Microvascular Endothelial Cells (IM-HBMEC) are a specialized cell line developed by immortalizing primary cells using SV40 Large T antigen. These cells have been extensively characterized and demonstrated to maintain the immune barrier properties of primary HBMECs. Flow cytometric analysis comparing IM-HBMEC with primary HBMECs revealed no significant differences in leukocyte migration responses or inflammatory cytokine production. Additionally, IM-HBMECs exhibited similar responses to astrocyte coculture, leukocyte stimulation, and inflammatory cytokine treatment. The immortalized cells showed remarkable longevity, with the ability to undergo more than 30 passages compared to the senescence observed in primary cells after the 3rd passage.
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