Studying the absorption and toxicity of inhaled drugs or chemicals requires a model reflecting the essential features of the air-blood barrier. For this purpose, AcceGen developed a novel alveolar type I cell line using the CI-SCREEN technology.
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The Immortalized Human Alveolar Epithelial Cell Line, derived from the alveolar epithelium of the lungs, addresses the challenge of limited cell lifespan inherent in primary cells. Through genetic manipulation or viral transformation, these cells overcome the natural limitations, ensuring an indefinite lifespan. This cell line serves as a crucial resource in lung research, where primary human alveolar epithelial cells are scarce. Unlike existing cell lines, it more accurately recapitulates the phenotype, functionality, and molecular characteristics of healthy human alveolar epithelium.
Studying the absorption and toxicity of inhaled drugs or chemicals demands a model that faithfully represents the essential features of the air-blood barrier. The Immortalized Human Alveolar Epithelial Cell Line provides precisely such a model, offering researchers a reliable platform to investigate these crucial aspects of lung physiology and pharmacology.
Why choose Immortalized Human Alveolar Epithelial Cell Line from AcceGen?
AcceGen’s Immortalized Human Alveolar Epithelial Cell Line faithfully replicates the crucial features of the air-blood barrier, providing an invaluable tool for biomedical studies.
Key Features:
Sterility Assurance:
Rigorously tested for contamination, including bacterial, fungal, and Mycoplasma (PCR).
Certified negative for human pathogens, ensuring the integrity of your experiments.
Optimal Viability:
Boasting high post-thaw viability, our cell line ensures robust and reliable results in your investigations.
Exceptional Growth Characteristics:
Demonstrates optimal growth based on distinct morphology and immunocytochemistry of multiple undifferentiation markers.
Species
Human
Cat.No
ABI-TC050D
Product Category
Immortalized Cell Lines
Size/Quantity
1 vial
Cell Type
Epithelial
Shipping Info
Dry Ice
Growth Conditions
37 ℃, 5% CO2
Source Organ
Alveolus
Disease
Normal
Storage
Liquid Nitrogen
Product Type
Immortalized Cell Line
Citation
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
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Application
FOR RESEARCH USE ONLY
The Immortalized Human Alveolar Epithelial Cell Line finds diverse applications in scientific research, particularly in the field of respiratory physiology and pathology. Some key applications include:
Disease Modeling
These cells serve as valuable tools for studying various respiratory diseases, such as pulmonary fibrosis, acute respiratory distress syndrome (ARDS), and lung cancer. Researchers can investigate disease mechanisms, screen potential therapeutic agents, and explore novel treatment strategies using this cell line.
Drug Absorption and Toxicity Studies
The cell line provides a relevant in vitro model for assessing the absorption, distribution, metabolism, and excretion (ADME) of inhaled drugs and chemicals. Additionally, researchers can evaluate the toxicity and adverse effects of environmental pollutants, nanoparticles, and pharmaceutical compounds on alveolar epithelial cells.
Barrier Function Studies
As a representative model of the air-blood barrier, these cells enable the investigation of barrier integrity, permeability, and transport mechanisms. Researchers can explore factors influencing epithelial barrier function, such as cytokines, growth factors, and inflammatory mediators, contributing to our understanding of lung physiology and pathology.
Respiratory Infection Research
The cell line facilitates the study of host-pathogen interactions during respiratory infections, including viral, bacterial, and fungal infections. Researchers can investigate the mechanisms of pathogen entry, replication, and immune response activation within alveolar epithelial cells, aiding in the development of antiviral and antibacterial therapies.
Drug Development and Screening
Pharmaceutical companies utilize the cell line in preclinical drug development studies to assess the efficacy and safety of potential therapeutics targeting respiratory disorders. High-throughput screening assays using these cells enable the identification of promising drug candidates for further evaluation in animal models and clinical trials.
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