Immortalized Chicken Embryo Intestinal Epithelial Cells have been developed by immortalizing primary Chicken Embryo Intestinal Epithelial Cells with SV40 Large T antigen.
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Immortalized Chicken Embryo Intestinal Epithelial Cells refer to a type of cell line derived from the intestinal epithelium of chicken embryos that has been modified to have an extended lifespan, often indefinitely. These cells are typically used in research settings to study various aspects of intestinal biology, including epithelial cell function, host-pathogen interactions, mucosal immunity, and intestinal development.
The immortalization process involves introducing genetic modifications to the cells, often by introducing viral oncogenes or inactivating tumor suppressor genes, which allows the cells to bypass normal cellular senescence mechanisms and continue to proliferate indefinitely in culture.
These cells retain many of the characteristics of primary intestinal epithelial cells, including their morphology, gene expression profiles, and functional properties. However, they offer several advantages over primary cells, including a more stable and consistent phenotype, the ability to proliferate indefinitely, and the capacity to be easily propagated and manipulated in vitro.
Why choose Immortalized Chicken Embryo Intestinal Epithelial Cells Line from AcceGen?
Embark on a new era of poultry research with AcceGen’s groundbreaking solution – the Immortalized Chicken Embryo Intestinal Epithelial Cells.
Key Advantages:
Long-Term Viability
Overcome the limitations of short lifespans associated with primary cells, enabling prolonged and comprehensive studies.
Cost-Efficiency
Eliminate the need for expensive culture media, coatings, or the continuous use of live embryos for each isolation, ensuring a budget-friendly solution.
High-Throughput Screening
Tailored for large-scale screening, providing an efficient platform for extensive experimentation.
Stringent Quality Assurance
All cells undergo rigorous testing, ensuring negativity for mycoplasma, bacteria, yeast, and fungi.
Species
Chicken
Cat.No
ABI-H0013X
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category
Immortalized Cell Lines
Size/Quantity
1 vial
Cell Type
Epithelial
Shipping Info
Dry Ice
Growth Conditions
37 ℃, 5% CO2
Source Organ
Intestine
Disease
Normal
Biosafety Level
1
Storage
Liquid Nitrogen
Product Type
Immortalized Cell Line
Citation
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
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Application
FOR RESEARCH USE ONLY
The lack of an in vitro model of chicken intestinal cells is one of the most important limitations in applied poultry nutritional research. It has been developed a novel advantageous method to culture cIECs starting from chicken embryos. Enterocytes exert an absorptive and protective function in the intestine, and they encounter many different challenging factors such as feed, bacteria, and parasites. By establishing an Immortalized Chicken Embryo Intestinal Epithelial Cells in vitro model, researchers can gain insights into how enterocytes respond to these challenges and aid in the development of strategies to combat pathogens.
Immortalized Chicken Embryo Intestinal Epithelial Cells were able to generate a cytokine response during an inflammatory challenge, and showed to be susceptible to Eimeria tenella sporozoites invasion and generate a proper immune response to parasitic and lipopolysaccharide (Escherichia coli) stimulation. This immortalized cell line could be a cost-effective and easy-to-maintain model for all the public health, food safety, or research and pharmaceutical laboratories that study host-pathogen interactions, foodborne pathogens, and food or feed science in vitro.
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