IL22 Reporter HEK-293 Cell Line

Description

IL-22, discovered in the year 2000, belongs to the IL-10 family. The IL-22 gene encodes a 179-amino acid protein, which after removing the 33-amino acid signal peptide, becomes a secretory form of IL-22 composed of 146 amino acids. IL-22 binds to a heterodimeric transmembrane receptor complex composed of IL-22R1 and IL-10R2, activating the JAK1-STATs pathway to produce corresponding functional effects. Additionally, there is a secretory receptor IL-22BP that blocks IL-22 signaling by binding to it. IL-22 does not directly regulate the function of white blood cells but targets cells of the frontline defense system, such as respiratory epithelial cells. Its role can be in immune regulation or pro-inflammatory response. IL-22 may also exert its defense function by upregulating chemotactic factors in the lungs and preventing lung damage during the acute phase of inflammation (e.g. fungal infections, pneumonia, initial stages of allergic airway inflammation). The IL22 Reporter 293 SSCell Line is a cell line based on the JAK-STAT signaling pathway, containing a Luciferase reporter gene. When IL-22 binds to IL-22Rα1 and IL10Rβ receptors, it activates the STATs signaling pathway, thereby inducing the expression of luciferase. The luciferase readout represents the activation effect of the signaling pathway and can be used for in vitro evaluation of IL-22-related drugs.