Inquiring IL-31RA OSMR Baf3 Cell Line
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| Species | Mouse |
| Cat.No | ABC-X0612F |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Transfected Stable Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphoblast |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lymphatic |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Overexpression Stable Cell Lines |
| Host Cell | Baf3 |
Interleukin-31 (IL-31) is a novel cytokine that belongs to the IL-6 cytokine family, with its receptor being similar to the IL-6 receptor. It is primarily secreted by activated CD4+ T lymphocytes, especially activated Th2 cells, mast cells, macrophages, and dendritic cells. IL-31 mainly regulates cell-mediated immunity in the skin by perceiving itch through the peripheral nervous system, modulates lung immunity by increasing airway inflammation, and adjusts intestinal immunity by defending against microbes.IL-31 forms a heterodimer complex signaling through the IL31RA and OSMR (oncostatin M receptor) receptors, closely associated with chronic pruritic skin diseases like atopic dermatitis. Monoclonal antibodies targeting IL-31 or its receptor can effectively reduce itching and sleep disturbances, improve skin lesions, and minimize the use of topical steroids.BA/F3 cells, dependent on IL-3 for growth, can be sustained by IL-31 protein instead of IL-3. Blocking this action with IL-31-related antagonists leads to concentration-dependent cell death. Therefore, evaluating the activity of IL-31-related inhibitors can be done by assessing cell viability.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
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