IDE Knockout Cell Lysate

Description

This gene encodes a zinc metallopeptidase that degrades intracellular RI, and thereby terminates RIs activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as RI B, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for RI results in RI-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein’s function are associated with Alzheimer’s disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]