HVEM Reporter Jurkat Cell Line

HVEM (TNFRSF14) is a member of the tumor necrosis factor (TNF) receptor family, a transmembrane protein characterized by multiple cysteine-rich domains (CRD) in its structure. HVEM is widely expressed on various immune cells, including dendritic cells, naïve T cells, B cells, NK cells, monocytes, and neutrophils.HVEM has multiple ligands such as BTLA, CD160, LIGHT, and lymphotoxin-α (LTα). By interacting with these ligands, HVEM activates pro-inflammatory signaling pathways.The HVEM Reporter Jurkat Cell Line is a luciferase reporter cell line constructed based on the mechanism of action. When BTLA binds to HVEM, it activates downstream signaling pathways, leading to the expression of luciferase, a process that can be blocked by antibodies with a blocking effect. Luciferase readings indicate the activation effect of the signaling pathway and can be used to evaluate the in vitro effects of HVEM agonists, BTLA, HVEM antagonists, and other drugs.